Resveratrol attenuates radiation damage in Caenorhabditis elegans by preventing oxidative stress

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  • YE Kan
    School of Radiation Medicine and Public Health, Medical College of Soochow University Department of Pediatrics, Affiliated Suzhou Hospital of Nanjing Medical University
  • JI Chen-Bo
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University Institute of Pediatrics, Nanjing Medical University
  • LU Xiao-Wei
    Department of Gerontology, the First Affiliated Hospital of Nanjing Medical University
  • NI Yu-Hui
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University
  • GAO Chun-Lin
    Institute of Pediatrics, Nanjing Medical University
  • CHEN Xiao-Hui
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University Institute of Pediatrics, Nanjing Medical University
  • ZHAO Ya-Ping
    Institute of Pediatrics, Nanjing Medical University
  • GU Gui-Xiong
    School of Radiation Medicine and Public Health, Medical College of Soochow University
  • GUO Xi-Rong
    Department of Pediatrics, Nanjing Maternal and Child Health Hospital of Nanjing Medical University Institute of Pediatrics, Nanjing Medical University

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  • Resveratrol Attenuates Radiation Damage in <i>Caenorhabditis elegans</i> by Preventing Oxidative Stress

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Resveratrol, a member of a class of polyphenolic compounds known as flavonols, has been extensively studied for its anticancer, antiviral, anti-inflammatory, and neuroprotective roles. Caenorhabidits elegans is a well-established animal for investigating responses to radiation. We found that resveratrol may provide protection against hazardous radiation. Pre-treatment with resveratrol extended both the maximum and mean life span of irradiated C. elegans. Resveratrol acted as a strong radical scavenger and regulated superoxide dismutase (SOD) expression. In addition, resveratrol was shown to be capable of alleviating γ-ray radiation exposure-induced reduction in mitochondrial SOD expression. Ultimately, a correlation may exist between dietary intake of trace amounts of resveratrol and anti-aging effects. A specific response mechanism may be activated after the administration of resveratrol in irradiated animals. Our results suggest the protective effect of resveratrol is due to its strong ability to protect from oxidative stress and protective effects in mitochondria. Therefore, resveratrol is potentially an effective protecting agent against irradiative damage.

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