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    • Radioprotection of Swiss Albino Mice by Myristica fragrans houtt

    DOI NDLデジタルコレクション NDLデジタルコレクション PDF Web Site ほか1件をすべて表示 一部だけ表示 被引用文献1件 参考文献55件
    • SHARMA Mini
      Cell and Molecular Biology Lab, Department of Zoology, University of Rajasthan
    • KUMAR Madhu
      Cell and Molecular Biology Lab, Department of Zoology, University of Rajasthan

    書誌事項

    公開日
    2007
    DOI
    • 10.1269/jrr.0637
    公開者
    Journal of Radiation Research 編集委員会

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    説明

    Nutmeg, the dried seed kernel of Myristica fragrans, MF (Family: Myristicaceae) possesses antifungal, hepatoprotective and antioxidant properties. Its radioprotective effect against 6, 8 and10 Gy gamma radiation was evaluated by 30 day survival assay. Regression analysis yielded LD50/30 as 6.83 Gy and 8.89 Gy for irradiated only and (MF + radiation) groups, respectively. The dose reduction factor was computed as 1.3. Administration of MF significantly enhanced hepatic glutathione (GSH) and decreased testicular lipid peroxidation (LPO) level whereas acid phosphatase (ACP) and alkaline phosphatase (ALP) activity did not show any significant alteration. Irradiation resulted in significant elevation in LPO level and ACP activity, and decreased the GSH content and ALP activity. MF pretreatment effectively protected against radiation induced biochemical alteration as reflected by a decrease in LPO level and ACP activity, and an increase in GSH and ALP activity. The present study has implications for the potential use of MF as a radioprotector.<br>

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