Whole Body Exposure to Low-dose Gamma Radiation Promotes Kidney Antioxidant Status in Balb/c Mice
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- PATHAK Chander Mohan
- Postgraduate Institute of Medical Education and Research
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- AVTI Pramod Kumar
- Postgraduate Institute of Medical Education and Research
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- KUMAR Surender
- Postgraduate Institute of Medical Education and Research
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- KHANDUJA Krishan Lal
- Postgraduate Institute of Medical Education and Research
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- SHARMA Suresh Chander
- Departments of Biophysics and Radiotherapy
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We examined the effect of whole body low-dose γ-irradiation on the status of the antioxidant defense system in the rodent kidneys at different time intervals. Young male Balb/c mice were exposed to whole body radiation from a 60Co source at doses of 10, 25 and 50 cGy (48.78 cGy/min). Antioxidant status and lipid peroxidation were estimated in the kidneys at 4, 12 and 24 h after irradiation. Lipid peroxidation increased between 33% and 49% and reduced glutathione between 12% and 47% at 12 h at different radiation doses. Reduced glutathione level remained significantly (p < 0.05) elevated even at 24 h after irradiation to 25 cGy. Superoxide dismutase activity also increased by 37% at 12 h on exposure of animals to all the doses up to 50 cGy. Catalase activity increased significantly at 12 h on exposure to 10 cGy and 50 cGy. Interestingly, glutathione peroxidase activity increased by 31% at 4 h and subsequently returned to control levels at 24 h after exposure to 50 cGy. Glutathione reductase activity increased by 10-12% at 12 h after exposure to 25 cGy and 50 cGy. The results suggest that the whole body exposure of animals to gamma radiation stimulates the antioxidant defense system in the kidneys within 4 to 24 h after irradiation, at doses of 25 cGy and 50 cGy.<br>
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 48 (2), 113-120, 2007
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001205217361664
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- NII論文ID
- 110006241798
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- NII書誌ID
- AA00705792
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- COI
- 1:STN:280:DC%2BD2s7ovFChsA%3D%3D
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 8691297
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可