Low-Dose Whole-Body Irradiation Induced Radioadaptive Response in C57BL/6 Mice
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- ITO Masato
- Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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- SHIBAMOTO Yuta
- Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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- AYAKAWA Shiho
- Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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- TOMITA Natsuo
- Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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- SUGIE Chikao
- Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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- OGINO Hiroyuki
- Department of Radiology, Nagoya City University Graduate School of Medical Sciences
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抄録
Radioadaptive survival responses after relatively low doses of radiation were investigated in C57BL/6 mice. The 8-week-old mice received whole-body mid-lethal challenging irradiation (5.9 Gy) at various intervals after conditioning whole-body irradiation with 50-400 mGy. Thereafter, survival of the mice was observed for 30 days. The mice receiving 400 mGy at 6 h before the challenging dose had a lower survival rate than the control group, but it was not observed when the conditioning 400-mGy irradiation was given 24 h beforehand. The conditioning doses of 100 and 200 mGy did not influence the survival of mice after the challenging dose. The mice receiving 50 mGy at 1 day, 3 days or 1 week before the challenging dose had a higher survival rate than the control, although this adaptive response was not observed when 50 mGy was given 6 h, 12 h, 3.5 weeks, or 5 weeks beforehand. When 50 mGy was given 2 weeks before the challenging dose, the adaptive response was observed in an experiment in which the mice were caged in our laboratory at the age of 5 weeks, whereas it was not observed in another experiment in which the mice were caged at 3 weeks. This study confirmed the presence of radioadaptive survival responses at the dose of 50 mGy given relatively shortly before the challenging dose.<br>
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 48 (6), 455-460, 2007
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001205217629952
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- NII論文ID
- 110006452327
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- NII書誌ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 9256478
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- 使用不可