Low Dose Radiation Increased the Therapeutic Efficacy of Cyclophosphamide on S180 Sarcoma Bearing Mice
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- YU Hong-Sheng
- The Department of Oncology, Affiliated Hospital of Qingdao University
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- XUE Hong-Wei
- The Department of Oncology, Affiliated Hospital of Qingdao University
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- GUO Chun-Bao
- The Laboratory of Surgery, Children's Hospital of Chongqing Medical University
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- SONG Ai-Qin
- The Department of Oncology, Affiliated Hospital of Qingdao University
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- SHEN Fang-Zhen
- The Department of Oncology, Affiliated Hospital of Qingdao University
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- LIANG Jun
- The Department of Oncology, Affiliated Hospital of Qingdao University
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- DENG Chun
- The Laboratory of Surgery, Children's Hospital of Chongqing Medical University
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抄録
We examined whether low dose radiation (LDR) exposure (75 mGy) could increase the therapeutic efficacy of cyclophosphamide (CTX) by comparing the effects of tumor suppression, tumor cell apoptosis, cell cycle and proliferation of bone marrow in vivo. Kunming mice implanted with S180 sarcoma cells were given 75 mGy whole body γ-ray radiation exposure and CTX (300 mg/kg) by intraperitoneal injection 36 hours after LDR. Proliferation of bone marrow and tumor cells was analyzed by flow cytometry. Cytochrome c leakage from the tumor was measured by Western-blot. We discovered that tumor growth was significantly reduced in the group exposed to CTX add to LDR. The apoptosis of tumor cells increased significantly after LDR. The tumor cells were arrested in G1 phase in the groups treated with CTX and CTX + LDR, but cell cycle was more significantly arrested in mice exposed to LDR followed by CTX than in mice exposed only to LDR or CTX chemotherapy. Concentration of bone marrow cells and proliferation index in CTX + LDR mice were higher than those in the untreated mice. LDR or CTX + LDR could induce greater cytochrome c levels and caspase-3 activity in tumors. These results suggest that low dose radiation can enhance the anti-tumor effect of the chemotherapy agent CTX markedly. Furthermore, LDR significantly protects hematopoetic function of the bone marrow, which is of practical significance on adjuvant chemotherapy.<br>
収録刊行物
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- Journal of Radiation Research
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Journal of Radiation Research 48 (4), 281-288, 2007
Journal of Radiation Research 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390001205217983616
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- NII論文ID
- 110006343941
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- NII書誌ID
- AA00705792
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- ISSN
- 13499157
- 04493060
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- NDL書誌ID
- 8811711
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- NDL-Digital
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可