Clinical Results of Carbon Ion Radiotherapy at NIRS

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  • TSUJII Hirohiko
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • MIZOE Junetsu
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • KAMADA Tadashi
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • BABA Masayuki
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • TSUJI Hiroshi
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • KATO Hirotoshi
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • KATO Shingo
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • YAMADA Shigeru
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • YASUDA Shigeo
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • OHNO Tatsuya
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • YANAGI Takeshi
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • IMAI Reiko
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • KAGEI Kenji
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • KATO Hiroyuki
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • HARA Ryusuke
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • HASEGAWA Azusa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • NAKAJIMA Mio
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • SUGANE Norio
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • TAMAKI Noriaki
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • TAKAGI Ryo
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • KANDATSU Susumu
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • YOSHIKAWA Kyosan
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • KISHIMOTO Riwa
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences
  • MIYAMOTO Tadaaki
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences

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  • Miyamoto clinical results of carbon ion radiotherapy at NIRS

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In 1994 a Phase I/II clinical study on carbon ion radiotherapy was begun at NIRS using HIMAC, which was then the world's only heavy ion accelerator complex dedicated to medical use in a hospital environment. Among several types of ion species, we have chosen carbon ions for cancer therapy because they had the most optimal properties in terms of possessing, both physically and biologically, the most effective dose-localization in the body. The purpose of the clinical study was to investigate the efficacy of carbon ion radiotherapy against a variety of tumors as well as to develop effective techniques for delivering an efficient dose to the tumor. The RBE of carbon ions was estimated to be 2.0 to 3.0 along the SOBP for acute skin reactions. As of August 2006, a total of 2,867 patients had been entered into Phase I/II or Phase II studies and analyzed for toxicity and local tumor response. The results have shown that carbon ion radiotherapy has the potential ability to provide a sufficient dose to the tumor with acceptable morbidity in the surrounding normal tissues. Tumors that appear to respond favorably to carbon ions include locally advanced tumors and those with histologically non-squamous cell type of tumors such as adenocarcinoma, adenoid cystic carcinoma, malignant melanoma, hepatoma, and bone/soft tissue sarcoma. By taking advantage of the biological and physical properties of high-LET radiation, the efficacy of treatment regimens with small fractions in short treatment times has been confirmed for almost all types of tumors in carbon ion radiotherapy.<br>

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