Acute Oral Toxicity Test of Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf in Rats

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  • HAYASHI Hirotaka
    Center for Innovation, Kanazawa University Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
  • OHTA Yasuyuki
    Graduate School of Natural Science and Technology, Kanazawa University
  • ARAI Takanari
    Endowed Center for the Advancement of Pregnancy, Perinatal and Infant Care, Kanazawa University Graduate School of Medical Science
  • SHIMANO Yasuko
    Graduate School of Natural Science and Technology, Kanazawa University
  • TAKANO Fumihide
    Graduate School of Natural Science and Technology, Kanazawa University
  • STRONG Jeffry Michael
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University
  • ENOMOTO Toshiki
    Department of Food Science, Ishikawa Prefectural University
  • UEBABA Kazuo
    Department of Presymptomatic Health Promotion Institute of Natural Medicine, University of Toyama
  • OHTA Tomihisa
    Graduate School of Natural Science and Technology, Kanazawa University
  • SUZUKI Nobutaka
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University

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Other Title
  • ハトムギ熱水抽出物のラット急性毒性試験

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Abstract

Coix lacryma-jobi L. var.ma-yuen Stapf (Coix seed) is a grass crop that has long been used in traditional medicine as a nourishing food. However, high-intake safety of the extract of the husks, pellicles and astringent skin of Coix seed has rarely been evaluated. We performed a safety test of hot water extract of all parts of Coix seed (CRD extract) in rats. CRD extract showed no significant toxicity on body weight, blood analyses, urinalysis and histopathological examination in acute toxicity tests.<br>

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