A Randomized Human Study on the Safety and Effectiveness of Powdered Food of <i>Agaricus blazei Murill</i>

  • UEBABA Kazuo
    Faculty of Health Science, Teikyo Heisei University
  • KYO Hoko
    Department of Complementary and Alternative Medicine Clinical R&D Kanazawa University Graduate School of Medical Science
  • SUZUKI Nobutaka
    Department of Complementary and Alternative Medicine Clinical R&D Kanazawa University Graduate School of Medical Science
  • URATA Teturo
    Urata Clinic, Hospy Medical Association

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Other Title
  • アガリクス<i> (Agaricus blazei Murill ) </i>粉末食品の安全性と有効性に関するランダム化ヒト試験
  • アガリクス(Agaricus blazei Murill)粉末食品の安全性と有効性に関するランダム化ヒト試験
  • アガリクス(Agaricus blazei Murill)フンマツ ショクヒン ノ アンゼンセイ ト ユウコウセイ ニ カンスル ランダムカ ヒト シケン

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Safety and effectiveness of powered food made from Agaricus blazei Murill was evaluated by a randomized human study. 45 healthy subjects were divided into 3 groups in sequence: control, 1 pack and 3 packs/day-administered groups. Each group had 15 persons. They had each packs for 28 days, and followed, in every two weeks, by the evaluation with CTCAE v3.0, QOL (SF36-v2), and biochemical examinations including liver/lung/kidney function, insulin resistance and NK activity and high-sensitivity CRP. None of them had adverse events nor biochemical/lung abnormal examinations. 1 and 3 packs-administered groups improved their QOL, high-sensitivity CRP and NK activity in a dose-dependent manner. These results ascertained safety, and effectiveness of the powdered food made from Agaricus blazei Murill against presymptomatic disorders including metabolic syndrome.

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