Daily Intake of Sulforaphane-Rich Broccoli Sprouts Suppresses H. pylori Colonization and Attenuates H. pylori-induced Gastritis via Upregulation of Nrf2-dependent Antixodaint Enzymes

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  • YANAKA Akinori
    Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • TAUCHI Masafumi
    Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba
  • YAMAMOTO Masayuki
    Tohoku University School of Medicine
  • HYODO Ichinosuke
    Department of Gastroenterology, Graduate School of Comprehensive Human Sciences, University of Tsukuba

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  • スルフォラファン含有食品，ブロッコリースプラウト摂取によるＨ．ｐｙｌｏｒｉ胃炎軽減作用と胃癌予防の可能性
  • スルフォラファン ガンユウ ショクヒン ブロッコリー スプラウト セッシュ ニ ヨル H pylori イエン ケイゲン サヨウ ト イガン ヨボウ ノ カノウセイ

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Background: Sulforaphane (SFN), a compound abundant in broccoli sprouts (BS), protects cells from oxidative injury by activating nrf2-mediated antioxidant enzymes. Sulforaphane also shows bactericidal activity against H. pylori in vitro. The aim of this study was to determine if daily intake of SFN-rich BS inhibits H. pylori colonization and mitigated gastritis in H. pylori-infected gastric mucosa in mice and humans.<br> Methods: Study 1: Nrf2+/+ and nrf2−/− C57BL/6 female mice were infected with H.pylori Sydney Strain; SS1. Mice were maintained for 2 mo. on a high salt diet (7.5% NaCl), supplemented with or without BS containing approximately 2.5 mM SFN. Degree of gastritis was evaluated by updated Sydney system. Study 2: Fifty subjects infected with H. pylori were randomly assigned to either the BS group (n=25) or the Alfalfa Sprouts (AS) group (n=25). All subjects were asked to eat BS 70 g/day (containing approximately 180 mg SFN) or AS 70 g/day (no SFN) for 2 months. H.pylori colonization was evaluated by measurement of HpSA. The degree of gastritis was evaluated by measuring serum levels of pepsinogen (PG) I and II.<br> Results: Study 1: BS treatment decreased Hp colonization and mitigated gastritis in nrf2+/+ but not in nrf2−/− mice. Study 2: Two months intervention with BS decreased HpSA values and serum levels of PG I and II, while AS showed on effect.<br> Conclusion: Daily intake of SFN-rich BS suppresses H.pylori colonization and improves gastritis in H. pylori-infected gastric mucosa via nrf2-dependent mechanisms.<br>

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