The Effects of Lactic Fermenting Beverage ANP71 on Defecation -An Open Clinical Trial-

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  • KYO Hoko
    Department of Complementary and Alternative Medicine Clinical research and Development, Kanazawa University Graduate School of Medical Science
  • UEBABA Kazuo
    Faculty of Health Care, Teikyo Heisei University
  • ABE Tetsuro
    Kanazawa University Graduate School of Medical, Pharmaceutical and Health Sciences, Laboratory of Environmental and Health Sciences
  • HASHIMOTO Shintaro
    Daimyomachi Skin Clinic
  • OHTA Tomihisa
    Kanazawa University Graduate School of Medical, Pharmaceutical and Health Sciences, Laboratory of Environmental and Health Sciences
  • SUZUKI Nobutaka
    Department of Complementary and Alternative Medicine Clinical research and Development, Kanazawa University Graduate School of Medical Science

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  • 乳酸菌飲料ANP71の排便状況に及ぼす影響 -オープン臨床試験-
  • ニュウサンキン インリョウ ANP71 ノ ハイベン ジョウキョウ ニ オヨボス エイキョウ : オープン リンショウ シケン

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Abstract

Objectives: The aim of this study is to examine the effects of lactic fermenting beverage ANP71 on defecation, blood pressure, immune function, constitution of Traditional Chinese Medicine (TCM) and safety. Methods: An open Clinical study was conducted on 15 healthy adults (female 11, male 4). ANP71 150ml per day was administrated for 4 weeks. At week 0, 1 and 4, blood samples were collected. blood pressure, immune function and constitution were measured. Results:① Defecation amount and exhilarating feeling increased. Abdominal feeling of fullness decreased.② Decrease of blood pressure was observed. ③ The change of parameters of blood biochemistry was in normal range. ④ Humoral immunity was predominant(Th1/Th2 decreased). ⑤ In constitution of TCM, Gentleness type, Yang-deficiency type, Yin-deficiency type, Phlegm-wetness type, wet-heat type and Qi-depression type were improved. ⑥ No significant adverse events were observed. Conclusion: Lactic fermenting beverage ANP71 appears to have benefits in improving defecation and constitutional problems. Various other biological effects of ANP71 were also observed.

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