Ribosome Profiling for Biomarker Discovery
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- SAKO Hiroaki
- Graduate School of Sport Sciences, Waseda University
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- SUZUKI Katsuhiko
- Faculty of Sport Sciences, Waseda University
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- TAKEYAMA Haruko
- Faculty of Science and Engineering, Waseda University
Bibliographic Information
- Other Title
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- リボソームプロファイリングのバイオマーカー開発への応用
- リボソームプロファイリング ノ バイオマーカー カイハツ エ ノ オウヨウ
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Abstract
It has been well known that protein level is estimated by the expression level of its mRNA. However, it is also argued that correlation between mRNA abundance and protein levels is weaker than previously thought. Recently a newly developed technique called ribosome profiling has drawn attention as a drastic countermeasure to improve the weak correlation. Here it is discussed that weak association of protein and mRNA levels seen in genome-wide analysis of gene expression such as microarray is attributable to post-transcriptional regulation including translational inhibition. This review further discusses how these issues are resolved by ribosome profiling and also addresses a possibility of biomarker discovery derived from this technique.<br>
Journal
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- Japanese Journal of Complementary and Alternative Medicine
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Japanese Journal of Complementary and Alternative Medicine 10 (1), 1-7, 2013
The Japanese Society for Complementary and Alternative Medicine
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Details 詳細情報について
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- CRID
- 1390001205219103360
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- NII Article ID
- 130003365071
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- NII Book ID
- AA12095429
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- ISSN
- 13487930
- 13487922
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- NDL BIB ID
- 024647031
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed