Safety Evaluation of Fucoidan from <i>Kjellmaniella Crassiforia</i> and Extract from <i>Hypsizigus Marmoreus</i>: Influence on the Activities and Gene Expressions of Rat Hepatic CYPs

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  • OHNOGI Hiromu
    TAKARA BIO INC
  • KUDO Yoko
    TAKARA BIO INC
  • HAYAMI Shoko
    TAKARA BIO INC
  • TAKIMOTO Yuko
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
  • SUZUKI Riho
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
  • SUZUKI Nobutaka
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science

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  • ガゴメ昆布フコイダンときのこテルペンエキスの安全性評価：ラット薬物代謝酵素への影響
  • ガゴメ コブ フコイダン ト キノコテルペンエキス ノ アンゼンセイ ヒョウカ : ラット ヤクブツ タイシャ コウソ エ ノ エイキョウ

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Abstract

Object: Gagome kombu (Kjellmaniella cracciforia) is the edible brown seaweed and contains fucoidan, a sulfated polysaccharide, abundantly. Bunashimeji (Hypsizigus marmoreus) is the popular Japanese mushrooms and contains polyterpenes as the bitter substance. Previously, we investigated the bioactive functions (e.g. anti-tumor action) and the safety of fucoidan from Gagome kombu (GKF) and the extract from Bunashimeji (KTE: Kinoko terpene extract). In this study, we evaluate the influence of GKF and KTE on hepatic cytochrome P450 (CYP).<br> Methods: Male SD rats were divided into three groups (n = 5). 2,000 mg/kg of GKF and KTE were given orally once daily for 4 days.<br> Result: There were no difference in activities and mRNA expressions of hepatic CYPs (CYP2C11, CYP2D, CYP2E1 and CYP3A1) among all groups.<br> Conclusion: These results indicated GKF and KTE did not influence the rat hepatic CYPs.<br>

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