Effects of Dietary Fish Oil on the Oxidative Stress in Obese Zucker Rats
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- HOSOYAMADA Yasue
- Department of Nutrition, Faculty of Health Care Sciences, Chiba Prefectural University of Health Sciences
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- YAMADA Masako
- Department of Nutrition, Faculty of Health Care Sciences, Chiba Prefectural University of Health Sciences
Bibliographic Information
- Other Title
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- 肥満ラットの生体内酸化ストレスに及ぼす魚油の影響
- ヒマン ラット ノ セイタイナイ サンカ ストレス ニ オヨボス ギョユ ノ エイキョウ
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Abstract
Objectives: We studied the effects of the fish oil (FO) diet given to obese Zucker (fa/fa) fatty rats on the serum and liver lipids concentrations, serum oxidative stress and antioxidant levels using diacron-reactive oxygen metabolites (d-ROMs) test and biological antioxidant potential (BAP) test. Methods: The Zucker fatty rats of 5weeks male were fed with diet for 4 weeks. The experimental diets were used normal diet or high cholesterol diet (HC). The fatty rat were fed with diet containing 10% Lard, 10% FO, 10% Lard+HC, 10% FO+HC. It was measured the concentrations of serum and liver lipids, serum d-ROMs and BAP. The d-ROMs and BAP were measured using Free Radical Elective Evaluator. The liver tissue were stained with Hematoxylin-Eosin staining that was observed with light microscopy Results: Although there were no difference in the both d-ROMs and BAP value among the diet, the d-ROMs value was tend to decrease and the BAP value was tend to increase in the FO group. The concentration of liver total cholesterol and triglyceride were decreased in the FO+HC group compared to the HC group. The number of fat droplet in the liver tissue were decreased in the FO group. Conclusion: Since the fat droplets was decreased in the FO group, it can be considered that fat accumulation was reduced to relieve oxidative stress in vivo. Thus, fish oil is expected to inhibit the oxidative stress in fatty rats.
Journal
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- Japanese Journal of Complementary and Alternative Medicine
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Japanese Journal of Complementary and Alternative Medicine 13 (1), 13-19, 2016
The Japanese Society for Complementary and Alternative Medicine
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Keywords
Details 詳細情報について
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- CRID
- 1390001205220131072
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- NII Article ID
- 130005145572
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- NII Book ID
- AA12095429
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- ISSN
- 13487930
- 13487922
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- NDL BIB ID
- 027305510
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed