Study of the Inhibitory Effect of <i>Coix lachryma-jobi</i> L. <i>var. ma-yuen</i> Stapf on Carcinogenesis and Inflammation

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  • SUZUKI Rihou
    The Division of Health Sciences, Kanazawa University Graduate School of Medical Science
  • TOKUDA Harukuni
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
  • SUZUKIi Nobutaka
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
  • UEBABA Kazuo
    Institute of Eastern Medicine, Teikyo Heisei University
  • XU FengHao
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
  • KAWABATA Toshiki
    Department of Complementary and Alternative Medicine Clinical Research and Development, Kanazawa University Graduate School of Medical Science
  • OHTA Tomihisa
    College of Medicinal Pharmaceutical and Health Sciences Laboratory of Environmental and Health Sciences, Kanazawa University
  • OHTAKE Shigeki
    Department of Clinical Laboratory Science, School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University

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Other Title
  • ハトムギの抗腫瘍ならびに抗炎症作用に関する検討
  • ハトムギ ノ コウシュヨウ ナラビニ コウエンショウ サヨウ ニ カンスル ケントウ

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Adlay( Coix lachryma-jobi L. var. ma-yuen Stapf ) is a grass crop that has long been used in traditional medicine as a nourishing food. This study investigated the inhibitory effects of adlay related substances on carcinogenesis and anti-inflammation. The hot water extract of all parts of adlay (CRD) were compared with the hot water extract of dehulled adlay (yokuinin). In addition, the Monoolein and Trilinolein components of adlay were compared.<br> As a screening date, antiproliferative effect of human cancer cells showed weak biological potency on physical dose response. Prevention effect of carcinogenesis and anti-inflammatory effect were also observed in all samplles. CRD showed stronger anti-UVB inflammatory effect than that of yokuinin; while yokuinin showed stronger anti-heating injury inflammatory effect than that of CRD. Moreover, Monoolein showed stronger effect than Trilinolein on both prevention effect of carcinogenesis and anti-inflammatory effect. These result indicated that these two extracts of adlay exhibited inhibitory effect on both tumor and inflammation. In addition, it is also suggested that Monoolein is more effective than Trilinolein.<br>

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