Developmental Signaling Disorders in Craniofacial Anomalies and Cancers
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- Zhang Yan
- Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
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- Wang Hua
- Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
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- Kamegai Akihide
- Oral and Maxillofacial Surgery, Mitsubishi Kyoto Hospital
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- Hata Tsuyoshi
- Department of Oral and Maxillofacial Surgery, Kawasaki Medical College
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- Kitamura Naoya
- Department of Oral and Maxillofacial Surgery, Kawasaki Medical College
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- Hosoda Masaru
- Department of Oral and Maxillofacial Surgery, Kawasaki Medical College
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- Tani Ryouji
- Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
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- Hayashido Yasutaka
- Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
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- Toratani Shigeaki
- Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
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- Okamoto Tetsuji
- Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
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Abstract
Normal human development requires the precise functioning and coordination of many complex pathways. Abnormalities in these signaling cascades often result in developmental perturbations, giving rise to congenital anomalies and cancers. There are 21,787 genes in each human nucleus, different gene subsets are expressed in different cell types, and different gene networks make different signal cascades. Among a large number of genes, in this review, we describe signaling disorders of sonic hedgehog and its receptor, patched-1; Tie2; fibroblast growth factor receptor in craniofacial anomalies and oral cancers.
Journal
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- Oral Science International
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Oral Science International 3 (2), 56-63, 2006
Japanese Stomatological Society
