Developmental Signaling Disorders in Craniofacial Anomalies and Cancers

DOI 37 References
  • Zhang Yan
    Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
  • Wang Hua
    Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
  • Kamegai Akihide
    Oral and Maxillofacial Surgery, Mitsubishi Kyoto Hospital
  • Hata Tsuyoshi
    Department of Oral and Maxillofacial Surgery, Kawasaki Medical College
  • Kitamura Naoya
    Department of Oral and Maxillofacial Surgery, Kawasaki Medical College
  • Hosoda Masaru
    Department of Oral and Maxillofacial Surgery, Kawasaki Medical College
  • Tani Ryouji
    Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
  • Hayashido Yasutaka
    Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
  • Toratani Shigeaki
    Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University
  • Okamoto Tetsuji
    Department Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University

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Description

Normal human development requires the precise functioning and coordination of many complex pathways. Abnormalities in these signaling cascades often result in developmental perturbations, giving rise to congenital anomalies and cancers. There are 21,787 genes in each human nucleus, different gene subsets are expressed in different cell types, and different gene networks make different signal cascades. Among a large number of genes, in this review, we describe signaling disorders of sonic hedgehog and its receptor, patched-1; Tie2; fibroblast growth factor receptor in craniofacial anomalies and oral cancers.

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