Altered fractionated radiotherapy has a survival benefit for head and neck cancers: Is it true?

DOI 1 Citations 23 References

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  • 非通常分割照射は頭頸部腫瘍において生存率向上に寄与しているのか？

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There was a significant survival benefit with altered fractionated radiotherapy, corresponding to an absolute benefit of 3.4% at 5 years. The benefit was significantly higher with hyperfractionated radiotherapy (8% at 5 years) than with accelerated radiotherapy (2% with accelerated fractionation without total dose reduction and 1.7% with total dose reduction at 5 years). The effect was greater for the primary tumor than for nodal disease. The effect was also more pronounced in younger patients and in those with good performance status. Hyperfractionation seemed to yield a more consistent advantage for survival than accelerated fractionated radiotherapy. However, accelerated radiotherapy might be associated with higher non-cancer related death. We have to evaluate whether the benefit of hyperfractionated radiotherapy versus standard radiotherapy persists when combined with concomitant chemotherapy and the benefit of IMRT compared with altered fractionation.

Journal

  • Toukeibu Gan

    Toukeibu Gan 33 (3), 289-292, 2007

    Japan Society for Head and Neck Cancer

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