Treatment strategy for hypopharyngeal cancer-From the viewpoint of the radiation oncologist-

DOI 4 Citations 13 References
  • Nakamura Katsumasa
    Department of Radiology, School of Medicine, Fukuoka University
  • Shioyama Yoshiyuki
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Nakashima Torahiko
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University
  • Nomoto Satoru
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Ohga Saiji
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Toba Takashi
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Yoshitake Tadamasa
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Komune Shizuo
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University
  • Kuratomi Yuichiro
    Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine, Saga University
  • Honda Hiroshi
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title
  • 下咽頭癌の治療戦略―放射線治療の立場から―
  • —From the viewpoint of the radiation oncologist—
  • ―放射線治療の立場から―

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Description

Chemoradiotherapy plays an important role in the treatment of hypopharyngeal cancer. At Kyushu University, patients with hypopharyngeal cancer are initially treated with 30-40 Gy of irradiation with chemotherapy. The patients who demonstrate a good response continue to receive further radiotherapy. The other patients with poor response to radiotherapy receive surgery. In 44 patients with stage I-II hypopharyngeal cancer, 32 patients received chemoradiotherapy and 11 patients received surgery. There were no significant differences in 5-year disease-specific survival rates between the two groups (88.4% vs 90.9%). Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with stage I disease, and in 23 (67.6%) of 34 patients with stage II disease. In 175 patients with stage III-IV hypopharyngeal cancer, 90 patients were treated with chemotherapy, and 85 patients were treated by surgery after preoperative chemoradiotherapy. There were no significant differences in 5-year disease-specific survival rates between the two groups. However, 5-year local recurrence-free survival rates in radiotherapy group was 90.9% in T1, 59.7% in T2, 46.0% in T3, and 34.9% in T4. Patients with radiosensitive hypopharyngeal cancer seem to be curable with chemoradiotherapy, although local control rates should be improved.

Journal

  • Toukeibu Gan

    Toukeibu Gan 33 (3), 305-308, 2007

    Japan Society for Head and Neck Cancer

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