Ubiquity of log-normal distributions in intra-cellular reaction dynamic

  • Furusawa Chikara
    Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University ERATO Complex Systems Biology Project, JST
  • Suzuki Takao
    Department of Biotechnology, Graduate School of Engineering, Osaka University
  • Kashiwagi Akiko
    Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University
  • Yomo Tetsuya
    Department of Bioinformatics Engineering, Graduate School of Information Science and Technology, Osaka University Department of Biotechnology, Graduate School of Engineering, Osaka University Graduate School of Frontier Biosciences, Osaka University Department of Pure and Applied Sciences, University of Tokyo ERATO Complex Systems Biology Project, JST
  • Kaneko Kunihiko
    Graduate School of Frontier Biosciences, Osaka University Department of Pure and Applied Sciences, University of Tokyo ERATO Complex Systems Biology Project, JST

書誌事項

タイトル別名
  • Ubiquity of log-normal distributions in intra-cellular reaction dynamics

説明

The discovery of two fundamental laws concerning cellular dynamics with recursive growth is reported. Firstly, the chemical abundances measured over many cells were found to obey a log-normal distribution and secondly, the relationship between the average and standard deviation of the abundances was found to be linear. The ubiquity of these laws was explored both theoretically and experimentally. By means of a model with a catalytic reaction network, the laws were shown to exist near a critical state with efficient self-reproduction. Additionally, by measuring distributions of fluorescent proteins in bacteria cells, the ubiquity of log-normal distribution of protein abundances was confirmed. Relevance of these findings to cellular function and biological plasticity is briefly discussed.<br>

収録刊行物

  • BIOPHYSICS

    BIOPHYSICS 1 25-31, 2005

    日本生物物理学会

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