Evaluation of EEG abnormality and pharmacotherapy for developmental disorders

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  • Nakagawa Eiji
    Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry

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  • 発達障害とてんかん
  • ハッタツ ショウガイ ト テンカン

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<p>Purpose:In pharmacotherapy for developmental disorders, not only anti-psychotic drugs, but these drugs in combination with anti-epileptic drugs are effective for behavioral and psychiatric symptoms.　Until now, evidence of pharmacotherapy for developmental disorders associated with epilepsy has not been established.　We evaluated the EEG abnormalities and usefulness of anti-epileptic drugs in developmental disorders.</p><p>Method:A total of 220 patients were included in this study.　We examined the therapeutic effect of behavioral and psychiatric improvement.</p><p>Results:EEG abnormalities were present in 76% of subjects, epilepsy with complicated symptoms in 40% and sleep disturbance in 34%.　Almost all patients showed EEG abnormalities on the frontal areas.　EEG abnormalities in the frontal lobe seemed to be associated with high behavioral and psychiatric symptoms, with lower inhibitory control.　Almost all patients combining anti-psychotic drug with anti-epileptic drug therapy showed improvement.</p><p>Conclusion:Anti-epileptic drugs are effective in developmental disorders with EEG abnormalities.　In cases of EEG abnormalities, anti-epileptic drugs may be an alternative treatment in developmental disorders.</p>

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