Induction of ES cells from Human Bone Marrow Mesenchymal Stem Cells: Epigenetic Control and Initialization of the Cells
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- IZAWA Shunji
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- YAMAJI Kozo
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- HOSHIKA Tomohiro
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- NISHITANI Yoshihiro
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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- YOSHIYAMA Masahiro
- Department of Operative Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
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Tissue regeneration is an important issue in the field of operative dentistry. In a series of previous studies, we demonstrated that tumor necrosis factor (TNF)-α activates the potential for totipotency in human mesenchymal stem cells (hMSCs) and leads to the regeneration of target cells or tissues in the presence of appropriate environmental factors. We proposed that TNF-α is an essential activator of totipotency for hMSCs to differentiate into various types of cells. In this study, we focused on epigenetic control that is closely associated with initialization of cells and examined the expression levels of Oct4, which is a marker of initialization of epigenetic control using the transcription factor set of TNF-α and Activin A. Our results indicate that this transcription factor set induces initialization of hMSCs to ES cells.
収録刊行物
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- Journal of Oral Tissue Engineering
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Journal of Oral Tissue Engineering 11 (3), 220-226, 2014
日本再生歯科医学会
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詳細情報 詳細情報について
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- CRID
- 1390001205224496768
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- NII論文ID
- 130004941114
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- ISSN
- 18800823
- 13489623
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可