Rodent animal models of posttraumatic stress disorder(PTSD): Focus on stress-induced enhancement of conditioned fear

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  • Yamada Kazuo
    Institute of Psychology and Behavioral Neuroscience, University of Tsukuba
  • Ryoke Rie
    Institute of Psychology and Behavioral Neuroscience, University of Tsukuba
  • Ichitani Yukio
    Institute of Psychology and Behavioral Neuroscience, University of Tsukuba

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Other Title
  • 齧歯類を用いた心的外傷後ストレス障害(PTSD)動物モデル: ストレス誘発性恐怖反応増強効果に着目して
  • 教育講演 齧歯類を用いた心的外傷後ストレス障害(PTSD)動物モデル : ストレス誘発性恐怖反応増強効果に着目して
  • キョウイク コウエン ゲツシルイ オ モチイタ シンテキ ガイショウ ゴ ストレス ショウガイ(PTSD)ドウブツ モデル : ストレス ユウハツセイ キョウフ ハンノウ ゾウキョウ コウカ ニ チャクモク シテ

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Posttraumatic stress disorder(PTSD)is an anxiety disorder that may develop following exposure to a highly traumatic event. Although exposure-based cognitive behavior therapy is commonly used to treat PTSD, additional treatments, such as pharmacological agents, are needed to make the therapy more effective. Accordingly, many researchers have proposed to animal models to study the neurobiological mechanisms underlying PTSD. In the first pat of this paper, we explain Pavlovian fear conditioning and conditioned place preference which are typically used to measure aversive and euphoric emotional memories respectively. The second part explains stress-induced enhancement of conditioned fear in rats as a useful animal model of PTSD.

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