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Clinical Characteristics and Long-Term Outcomes of Hypertrophic Cardiomyopathy
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- Yoshinaga Masataka
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
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- Yoshikawa Daiji
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital Department of Cardiology, Nagoya University Graduate School of Medicine
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- Ishii Hideki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Hirashiki Akihiro
- Department of Advanced Medicine in Cardiopulmonary Disease, Nagoya University Graduate School of Medicine
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- Okumura Takahiro
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Kubota Aki
- Department of Hospital Pharmacy, Nagoya University Hospital
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- Sakai Shinichi
- Department of Cardiology, Kainan Hospital
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- Harada Ken
- Department of Cardiology, Chubu Rosai Hospital
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- Somura Fuji
- Department of Cardiology, Nagoya Central Hospital
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- Mizuno Tomofumi
- Department of Cardiology, Aichi Medical University
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- Fujiwara Wakaya
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
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- Yokoi Hiroatsu
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
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- Hayashi Mutsuharu
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital Department of Cardiology, Nagoya University Graduate School of Medicine
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- Ishii Junichi
- Department of Cardiology, Fujita Health University Hospital
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- Ozaki Yukio
- Department of Cardiology, Fujita Health University Hospital
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- Murohara Toyoaki
- Department of Cardiology, Nagoya University Graduate School of Medicine
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- Yoshida Yukihiko
- Department of Cardiology, Cardiovascular Center, Nagoya Daini Red Cross Hospital
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- Amano Tetsuya
- Department of Cardiology, Aichi Medical University
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- Izawa Hideo
- Department of Cardiology, Fujita Health University Banbuntane-Hotokukai Hospital
Bibliographic Information
- Other Title
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- Clinical characteristics and long-term outcome of hypertrophic cardiomyopathy. Results from the Aichi hypertrophic cardiomyopathy (AHC) registry
- Results from the Aichi Hypertrophic Cardiomyopathy (AHC) Registry
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Description
Hypertrophic cardiomyopathy (HCM) has various morphological and clinical features. A decade has passed since the previous survey of the epidemiological and clinical characteristics of Japanese HCM patients. The Aichi Hypertrophic Cardiomyopathy (AHC) Registry is based on a prospective multicenter observational study of HCM patients. The clinical characteristics of 42 ambulant HCM patients followed up for up to 5 years were investigated. The primary endpoint was major adverse cardiac events (MACE), defined as death, non-fatal stroke, admission due to congestive heart failure (CHF), or episodes of sustained ventricular tachycardia/fibrillation. The MACE-free survival during the 5-year follow-up period was 76% according to Kaplan–Meier analysis. HCM-related death occurred in 3 (7%) patients and SCD occurred in 2 (5%) patients. Additionally, 3 (7%) patients were admitted to the hospital due to CHF. Meanwhile, sustained VT was detected in one (2%) of the patients who received ICD implantation and subsequently terminated with antitachycardia pacing using an ICD. The patients with HCM exhibiting left ventricular outflow obstruction (HOCM) had a slightly lower MACE-free survival rate than those with neither HOCM nor dilated-HCM (dHCM) (71% versus 81%, log-rank P = 0.581). Furthermore, the patients with dHCM demonstrated a significantly lower MACE-free survival rate than those with neither HOCM nor dHCM (33% versus 81%, log-rank P = 0.029). In the AHC Registry targeting current Japanese HCM patients, we demonstrated that many HCM patients continue to suffer from MACE despite the development of various treatments for HCM.
Journal
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- International Heart Journal
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International Heart Journal 56 (4), 415-420, 2015
International Heart Journal Association
