Serum Interleukin-6 Levels, Not Genotype, Correlate With Coronary Plaque Complexity

DOI Web Site 被引用文献2件 参考文献23件
  • Kuo Li-Tang
    Cardiology Section, Department of Medicine, Chang Gung University College of Medicine, Chang Gung Memorial Hospital
  • Yang Ning-I
    Cardiology Section, Department of Medicine, Chang Gung University College of Medicine, Chang Gung Memorial Hospital
  • Cherng Wen-Jin
    Cardiology Section, Department of Medicine, Chang Gung University College of Medicine, Chang Gung Memorial Hospital
  • Verma Subodh
    Division of Cardiac Surgery, St. Michael’s Hospital
  • Hung Ming-Jui
    Cardiology Section, Department of Medicine, Chang Gung University College of Medicine, Chang Gung Memorial Hospital
  • Wang Shih-Yi
    Cardiology Section, Department of Medicine, Chang Gung University College of Medicine, Chang Gung Memorial Hospital
  • Liu Min-hui
    Department of Nursing, Chang Gung University College of Medicine, Chang Gung Memorial Hospital
  • Chen Shu-yi
    Department of Nursing, Chang Gung University College of Medicine, Chang Gung Memorial Hospital
  • Wang Chao-Hung
    Cardiology Section, Department of Medicine, Chang Gung University College of Medicine, Chang Gung Memorial Hospital

この論文をさがす

説明

An increased serum interleukin-6 (IL-6) level is associated with an increased risk of cardiovascular events in healthy subjects. However, it is unknown whether the level of serum IL-6 or genetic IL-6 polymorphism is correlated with the complexity of coronary plaque in patients with stable coronary artery disease (CAD). <br> Patients with stable CAD (n = 135) were divided into 3 groups: insignificant coronary plaque (n = 77), simple coronary plaque (n = 15), and complex coronary plaque (n = 43). IL-6-174G > C polymorphism and serum levels of IL-6 and C-reactive protein (CRP) were investigated. <br> No significant difference in the distribution of IL-6 genotypes was found among the groups. The presence of complex coronary plaque was associated with higher serum concentrations of IL-6 (P = 0.026) and CRP (P < 0.0001). To predict the presence of complex lesions, IL-6 > 5.8 ng/L and CRP > 2.6 mg/L had sensitivities of 86% and 74%, and specificities of 61% and 62%, respectively. By multivariate analysis, IL-6 > 5.8 ng/L and CRP > 2.6 mg/L were independently related to the presence of complex coronary plaque (P = 0.0002 and 0.004, respectively). IL-6 > 5.8 ng/L and CRP > 2.6 mg/L were associated with a 4.5-fold increase in the odds of having complex coronary plaque (P < 0.005).<br> A simple measurement of the serum IL-6 level in patients with CAD can potentially identify subjects with complex coronary lesions and provide the option of aggressive medical strategies in a clinical setting. <br>

収録刊行物

  • International Heart Journal

    International Heart Journal 49 (4), 391-402, 2008

    一般社団法人 インターナショナル・ハート・ジャーナル刊行会

被引用文献 (2)*注記

もっと見る

参考文献 (23)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ