Relationship between brain network and aging based on healthy subjects cohort findings

DOI Web Site
  • Watanabe Hirohisa
    Nagoya University, Brain and Mind Research Center Nagoya University Graduate School of Medicine, Department of Neurology
  • Sobue Gen
    Nagoya University, Brain and Mind Research Center Nagoya University Graduate School of Medicine

Bibliographic Information

Other Title
  • 健常コホートからみた脳内神経回路に加齢が及ぼす影響
  • 教育講演 健常コホートからみた脳内神経回路に加齢が及ぼす影響
  • キョウイク コウエン ケンジョウ コホート カラ ミタ ノウナイ シンケイ カイロ ニ カレイ ガ オヨボス エイキョウ

Search this article

Description

Visualization of anatomical and functional neural network changes associated with aging are important in order to develop reliable imaging biomarkers for very early diagnosis and breakthrough treatment of neurodegenerative dementia.　We have investigated the changes of the brain network in healthy subjects using resting-state functional MRI, diffusion tensor MRI, 3D MPRAGE, and magnetoencephalography.　Based on preliminary analysis with 200 healthy aging subjects, brain atrophy is observed mainly in limbic and premotor areas.　Diffusion tract imaging showed anatomical network disruption surrounding the lateral cerebral ventricle.　However, resting state functional MRI showed a decrease in resting connectivity in the fundamental resting state networks such as default mode network.　However, increases in resting connectivity across multiple functional ROIs were more frequently observed than decreases.　These results may be a compensatory phenomenon of functional brain networks against the progression of brain atrophy and disruption of anatomical brain networks with aging brain.　Dynamic remodeling of anatomical and functional networks appear to be occurring more widely in the aging brain than previously supposed.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top