Gene Expression of Adipocytokine Receptors during Osteoblastic Differentiation
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- KAMADA Aiko
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- IKEO Takashi
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- YOSHIKAWA Yoshihiro
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- DOMAE Eisuke
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- GODA Seiji
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- TAMURA Isao
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- TANABE Kaoru
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- TANABE Jun-ichi
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- ITSUSAKI Hiroshi
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- KINOSHITA Goichi
- Department of Biochemistry, Osaka Dental Univ., Osaka, Japan
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- KITANO Tadanori
- Department of Interdisciplinary Dentistry for Postgraduate Trainee, Osaka Dental Univ., Osaka, Japan
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- KIKUCHI Yuko
- Department of Interdisciplinary Dentistry for Postgraduate Trainee, Osaka Dental Univ., Osaka, Japan
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- OKAZAKI Joji
- Department of Removable Prosthodontics, Osaka Dental Univ., Osaka, Japan
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Abstract
In order to elucidate the involvement of adipocytokine action in bone formation, we demonstrated the expression of adipocytokine receptors, leptin receptor (LepR) and adiponectin receptors (AdipoR1 and AdipoR2), in cultured pro-osteoblastic cells during osteoblastic differentiation.<br>The mRNA expression levels of osteocalcin and Runx2 were increased significantly by culture with differential medium. Both adiponectin receptors, AdipoR1 and AdipoR2, were also increased significantly during osteoblastic differentiation, though there were no significant changes in the leptin receptor, LepR, level. This indicated that adiponectin rather than leptin may be involved in osteoblastic differentiation.<br>Circulating adiponectin includes both a full-length type and a globular type. We also investigated the effect of globular adiponectin (gAN) on the induction of osteoblastic properties. gAN significantly suppressed the induced gene expression of osteocalcin and adiponectin receptors.<br>Our results indicate that the expressions of adiponectin receptors may be involved in osteoblastic differentiation without involvement of the serum globular type of adiponectin.
Journal
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- Journal of Oral Tissue Engineering
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Journal of Oral Tissue Engineering 7 (1), 53-60, 2009
Japanese Association of Regenerative Dentistry
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Details 詳細情報について
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- CRID
- 1390001205226532992
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- NII Article ID
- 130004456604
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- ISSN
- 18800823
- 13489623
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- Text Lang
- en
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed