Comparison of Inflammatory Biomarkers in Outpatients With Prior Myocardial Infarction

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  • Ikeda Yuichi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Kumagai Hidetoshi
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, The University of Tokyo
  • Motozawa Yoshihiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
  • Suzuki Jun-ichi
    Department of Advanced Clinical Science and Therapeutics, Graduate School of Medicine, The University of Tokyo

書誌事項

タイトル別名
  • Growth Differentiation Factor 15 (GDF15) as a Reliable Biomarker for Cardiovascular Risk Assessment
公開日
2016
資源種別
journal article
DOI
  • 10.1536/ihj.15-324
  • 10.1536/ihj.15-197
公開者
一般社団法人 インターナショナル・ハート・ジャーナル刊行会

この論文をさがす

説明

Inflammatory biomarkers have been proposed for use in the risk stratification of patients with acute myocardial infarction (AMI). We examined the value of inflammatory biomarkers over clinical features for predicting cardiovascular (CV) events in stable outpatients with MI. We enrolled 430 post-MI patients and measured their levels of high-sensitivity C reactive protein (hs-CRP), growth differentiation factor-15 (GDF-15), and the interleukin-1 receptor family member called ST2 (ST2), one month after AMI. Patients were prospectively followed for 3 years. In our study cohort (mean age, 66 ± 12 years; left ventricular ejection fraction, 55 ± 13%), CV events were observed in 39 patients (9.1%). Kaplan– Meier analysis revealed that patients with high levels of GDF-15 (≥ 1221.0 ng/L) showed poorer prognoses than those with low levels of GDF-15 (< 1221.0 ng/L) (20.4% versus 3.6%, P < 0.001); hs-CRP and ST2 did not show a similar correlation with prognoses. GDF-15 remained associated with CV events after adjusting for age, chronic kidney disease, and B-type natriuretic peptide (hazard ratio, 1.001; 95% confidence interval, 1.000 – 1.001; P = 0.046). GDF-15 provided an incremental predictive value for CV events over clinical features (incremental value in global χ2 = 43.81, P < 0.001). In outpatients with prior MI, GDF-15 was an independent indicator of CV events, unlike hs-CRP and ST2. GDF15 provided an incremental prognostic value over clinical features.

収録刊行物

  • International Heart Journal

    International Heart Journal 57 (1), 1-2, 2016

    一般社団法人 インターナショナル・ハート・ジャーナル刊行会

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