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- Morita Hiroyuki
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
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- Komuro Issei
- Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo
書誌事項
- タイトル別名
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- Wnt/β-Catenin Signaling and p53 Pathway
この論文をさがす
説明
<p>The molecular pathophysiology of heart failure, which is one of the leading causes of mortality, is not yet fully understood. Heart failure can be regarded as a systemic syndrome of aging-related phenotypes. Wnt/β-catenin signaling and the p53 pathway, both of which are key regulators of aging, have been demonstrated to play a critical role in the pathogenesis of heart failure. Circulating C1q was identified as a novel activator of Wnt/β-catenin signaling, promoting systemic aging-related phenotypes including sarcopenia and heart failure. On the other hand, p53 induces the apoptosis of cardiomyocytes in the failing heart. In these molecular mechanisms, the cross-talk between cardiomyocytes and non-cardiomyocytes (e,g,. endothelial cells, fibroblasts, smooth muscle cells, macrophages) deserves mentioning. In this review, we summarize recent advances in the understanding of the molecular pathophysiology underlying heart failure, focusing on Wnt/β-catenin signaling and the p53 pathway.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 59 (1), 6-13, 2018
一般社団法人 インターナショナル・ハート・ジャーナル刊行会