Long-Term Efficacy of Amiodarone Therapy for the Prevention of Recurrence of Paroxysmal Atrial Fibrillation Analysis Based on Patient Characteristics
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- Tachibana Hideaki
- Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine
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- Komatsu Takashi
- Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine
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- Ozawa Mahito
- Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine
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- Kunugita Fusanori
- Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine
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- Sato Yoshihiro
- Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine
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- Nakamura Motoyuki
- Division of Cardiology, Department of Internal Medicine and Memorial Heart Center, Iwate Medical University School of Medicine
書誌事項
- タイトル別名
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- Analysis Based on Patient Characteristics
- 公開日
- 2011
- 資源種別
- journal article
- DOI
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- 10.1536/ihj.52.212
- 公開者
- 一般社団法人 インターナショナル・ハート・ジャーナル刊行会
この論文をさがす
説明
There is little information available on factors affecting the long-term prevention of paroxysmal atrial fibrillation (AF) in the Japanese population. A total of 71 patients (49 men, mean age, 68 ± 8 years) with paroxysmal AF refractory to ≥ 2 class I antiarrhythmic drugs received oral amiodarone (50-200 mg/day). All patients were observed for more than 12 months (mean follow-up period, 47 ± 26 months) and were analyzed on the basis of patient profiles. The percentage of patients with AF recurrence despite amiodarone therapy was 54% in all patients. In multivariate logistic regression analysis adjusted for age and sex, the following factors were associated with preventive efficacy for AF recurrence: left ventricular ejection fraction (LVEF) (relative risk [RR] 0.933, 95% confidence interval [CI] 0.877-0.993, P = 0.029), asymptomatic AF (RR 0.068, CI 0.005-0.870, P = 0.039), and AF occurring irrespective of circadian variation (RR 0.115, CI 0.013-0.988, P = 0.049). The percentage of patients with conversion to permanent AF despite amiodarone therapy was 31% in all patients. In multivariate logistic regression analysis adjusted for age and sex, asymptomatic AF (RR 0.085, CI 0.010-0.732, P = 0.025) was the only factor associated with preventive efficacy for conversion to permanent AF. Amiodarone appears to be effective in maintaining sinus rhythm, especially in patients with impaired left ventricular function. In contrast, amiodarone appears to be refractory in those with asymptomatic AF or AF occurring irrespective of circadian variation.
収録刊行物
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- International Heart Journal
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International Heart Journal 52 (4), 212-217, 2011
一般社団法人 インターナショナル・ハート・ジャーナル刊行会
