Psychiatric symptoms and their causes in patients with epilepsy: Focus on the negative effects of antiepileptic drugs

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  • てんかん患者に見られる精神症状とその原因
  • てんかん患者に見られる精神症状とその原因 : 抗てんかん薬を中心に
  • テンカン カンジャ ニ ミラレル セイシン ショウジョウ ト ソノ ゲンイン : コウテンカンクスリ オ チュウシン ニ
  • ──抗てんかん薬を中心に──

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Abstract

<p>Patients with epilepsy often show psychiatric symptoms.　The underlying mechanisms of their psychiatric symptoms consist of 1） basic brain functional disorder resulting in epilepsy, 2） direct effects of epileptic seizures and 3） various psycho-somatic effects during long-term course of illness.　Antiepileptic drugs influence all these mechanisms by various ways.　These are summarized as follows:1） direct effects by the drug per se, 2） increase or decrease in frequency of epileptic seizures by the drug and 3） individual vulnerability to psychiatric symptoms.　In order to reduce the occurrence of psychiatric symptoms, we should take into account characteristics of the drug and the individual vulnerability in selecting these drugs.　Administration of antiepileptic drug should begin with minimal doses and be slowly titrated.　In order to detect psychiatric symptoms promptly, we should give information about possible psychiatric symptoms to each patient in advance.　In case of appearance of psychiatric symptoms, we should first consider the negative effects of prescribed antiepileptic medication. </p>

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