Maoto, Kampo medicine, suppresses the metastatic potential of highly metastatic osteosarcoma cells
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- HYUGA Sumiko
- Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute
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- HYUGA Masashi
- Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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- NAKANISHI Hayao
- Division of Oncological Phathology, Aichi Cancer Center Research Institute
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- ITO Hidenori
- Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute Kitasato University Graduate School, Doctoral Program of Medical Science, Oriental Medicine
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- WATANABE Koji
- Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute Kitasato University Graduate School, Doctoral Program of Medical Science, Oriental Medicine
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- OIKAWA Tetsuro
- Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute
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- HANAWA Toshihiko
- Department of Clinical Research, Oriental Medicine Research Center, The Kitasato Institute Kitasato University Graduate School, Doctoral Program of Medical Science, Oriental Medicine
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抄録
Maoto, Kampo medicine, has been shown to inhibit the motility of highly metastatic osteosarcoma, FBJ-LL cells. In the present study, maoto was found to suppress the liver-metastasis of FBJ-LL cells and had no effect on the primary tumor growth. The expression pattern of cytokines in the serum from the tumor-bearing mice given maoto approximated that of the serum from normal mice and was different from that in the serum obtained from the tumor-bearing mice given water. Maoto suppressed the activation of matrix metalloproteinases involved in metastatic processes. On the other hand, juzentaihoto, which has been reported to suppress cancer metastasis via activation of the immune system, had no effect on either liver-metastasis of FBJ-LL cells or primary tumor growth. These results suggest that maoto is a candidate for a novel inhibitor of metastasis, and that the inhibition mechanism of metastasis is different from that of juzentaihoto.
収録刊行物
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- Journal of Traditional Medicines
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Journal of Traditional Medicines 24 (2), 51-58, 2007
和漢医薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001205233205120
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- NII論文ID
- 110006273627
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- NII書誌ID
- AA12035198
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- ISSN
- 18813747
- 18801447
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- NDL書誌ID
- 8813580
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可