Effect of a traditional Chinese medicine, maobushisaishinto, on the antibody titer after influenza vaccination: A randomized, placebo-controlled, double-blind trial

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  • TERASHIMA Yoshihiro
    Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • HAMAZAKI Kei
    Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • ITOMURA Miho
    Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • HUAN Mingming
    Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
  • SHIBAHARA Naotoshi
    Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
  • KOBAYASHI Satoru
    Department of Pharmacy, University Hospital, Tokyo Medical and Dental University
  • HAMAZAKI Tomohito
    Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama

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Background: It was shown that a traditional Chinese medicine, maobushisaishinto (MBST), had adjuvant effects on influenza vaccination in an animal experiment and an open trial in elderly subjects. <BR>Purpose: To examine the adjuvant effects of MBST in a closer clinical experiment.<BR>Methods: Forty-seven healthy subjects between 20 and 71 y of age were randomly assigned to two groups (control and MBST groups) in a double-blind manner. The subjects in the MBST group (n=23) took 1.68g spray-dried powder of MBST/day for two weeks; the rest (control subjects, n=24) took the same amount of indistinguishable placebo. Then subjects were vaccinated against influenza viruses (A/H1N1, A/H3N2 and B). Serum hemagglutination inhibition titers were measured at weeks 0, 1, 2, 4, and 12. <BR>Results: The titers against the three viruses were increased continuously for the first two weeks and leveled off. However, MBST was not superior to placebo in any titers.<BR>Conclusion: We could not find any adjuvant effects of MBST in this experimental condition.

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