Effect of a traditional Chinese medicine, maobushisaishinto, on the antibody titer after influenza vaccination: A randomized, placebo-controlled, double-blind trial
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- TERASHIMA Yoshihiro
- Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
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- HAMAZAKI Kei
- Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
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- ITOMURA Miho
- Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
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- HUAN Mingming
- Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
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- SHIBAHARA Naotoshi
- Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
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- KOBAYASHI Satoru
- Department of Pharmacy, University Hospital, Tokyo Medical and Dental University
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- HAMAZAKI Tomohito
- Section of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama
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説明
Background: It was shown that a traditional Chinese medicine, maobushisaishinto (MBST), had adjuvant effects on influenza vaccination in an animal experiment and an open trial in elderly subjects. <BR>Purpose: To examine the adjuvant effects of MBST in a closer clinical experiment.<BR>Methods: Forty-seven healthy subjects between 20 and 71 y of age were randomly assigned to two groups (control and MBST groups) in a double-blind manner. The subjects in the MBST group (n=23) took 1.68g spray-dried powder of MBST/day for two weeks; the rest (control subjects, n=24) took the same amount of indistinguishable placebo. Then subjects were vaccinated against influenza viruses (A/H1N1, A/H3N2 and B). Serum hemagglutination inhibition titers were measured at weeks 0, 1, 2, 4, and 12. <BR>Results: The titers against the three viruses were increased continuously for the first two weeks and leveled off. However, MBST was not superior to placebo in any titers.<BR>Conclusion: We could not find any adjuvant effects of MBST in this experimental condition.
収録刊行物
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- Journal of Traditional Medicines
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Journal of Traditional Medicines 24 (2), 59-66, 2007
和漢医薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001205233206656
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- NII論文ID
- 110006273628
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- NII書誌ID
- AA12035198
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- ISSN
- 18813747
- 18801447
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- HANDLE
- 10110/1275
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- NDL書誌ID
- 8813603
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可