Characteristics of Thyrotoxic Patients Occasionally Diagnosed from Slight Changes in Clinical or Laboratory Findings in Regular Health Check-up

Nakamura Yasuko, Morimura Tadashi

doi:10.11320/ningendock.26.467

Objective: We report on 4 thyrotoxic patients occasionally diagnosed from very slight biochemical changes due to thyroid hormone increases in a regular health check-up.<br>Methods and Results: They themselves were not aware of being in the thyrotoxic state and neither were physicians who had examined them because there were no symptoms. The thyrotoxic state had been discovered in more detailed examinations conducted after the regular check-up. The reasons for doing this were palpable goiter in 2 patients, increased serum alkaline phosphatase with slight tachycardia in 1 patient and low serum cholesterol in 1 patient. Three patients were diagnosed with painless thyroiditis from very low uptake of radioactive iodine by the thyroid gland, and they recovered without any treatment. There were increases and decreases in their serum thyroid hormone levels during the following period, which finally returned to normal without any treatment. The remaining patient was diagnosed with Plummer disease. Her thyroid nodule was not palpable and only detectable in an ultra-sonogram and a scintigram, which revealed that the nodule was functioning.<br>Conclusion: The incidence of painless thyroiditis in thyrotoxic patients occasionally diagnosed in a regular health check-up was high. They did not have prominent clinical thyrotoxic signs or symptoms. It was diagnosed from small changes in their laboratory data due to increases in thyroid hormone levels.

Characteristics of Thyrotoxic Patients Occasionally Diagnosed from Slight Changes in Clinical or Laboratory Findings in Regular Health Check-up

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