Screening for Primary Hyperparathyroidism in Ningen Dock

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  • Higashi Kiichiro
    National Hospital Organization, Kumamoto Medical Center, Department of Diabetes and Endocrinology
  • Kodama Shoko
    National Hospital Organization, Kumamoto Medical Center, Department of Diabetes and Endocrinology
  • Toyonaga Tetsushi
    National Hospital Organization, Kumamoto Medical Center, Department of Diabetes and Endocrinology
  • Shimakawa Akiko
    National Hospital Organization, Kumamoto Medical Center, Department of Diabetes and Endocrinology
  • Shimada Sayaka
    National Hospital Organization, Kumamoto Medical Center, Department of Diabetes and Endocrinology
  • Takahashi Takeshi
    National Hospital Organization, Kumamoto Medical Center, Department of Diabetes and Endocrinology
  • Ichinose Yasuhiro
    National Hospital Organization, Kumamoto Medical Center, Department of Clinical Laboratory
  • Esumi Makoto
    National Hospital Organization, Kumamoto Medical Center, Department of Clinical Laboratory
  • Hisada Masatada
    National Hospital Organization, Kumamoto Medical Center, Department of Clinical Laboratory
  • Tsuruta Toshihisa
    National Hospital Organization, Kumamoto Medical Center, Department of Clinical Laboratory

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Other Title
  • 人間ドックにおける原発性副甲状腺機能亢進症のスクリーニング
  • ニンゲン ドック ニ オケル ゲンパツセイ フクコウジョウセン キノウ コウシンショウ ノ スクリーニング

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Abstract

Objective: We screened examinees with hypercalcemia in Ningen Dock for primary hyperparathyroidism.<br>Methods: Examinees were screened from July 1995 to December 2010. Serum calcium (Ca), phosphate and albumin (Alb) were measured using an auto-analyzer. Examinees with hypercalcemia were selected for primary hyperparathyroidism screening and their serum Ca levels were adjusted using serum Alb levels to provide corrected serum calcium(cCa) levels. For those with high serum Ca and cCa levels, serum parathyroid hormone(PTH)levels were measured for diagnosis of primary hyperparathyroidism. We also investigated examinees from July 2001 to December 2010 regarding a relationship between primary hyperparathyroidism and hypercalcemia. <br>Results: The total number of examinees was 1,936 (1,324 males, 612 females). The first case of serum high Ca and cCa levels was the 817th examinee since our Ningen Dock started, and the second was the 1,737th (920th case after first detected case). These 2 examinees were diagnosed with primary hyperparathyroidism due to high serum PTH levels. When we investigated 1,615 examinees during the period July 2001 to December 2010, high serum Ca levels were detected in 24 cases(1.5%). High serum cCa levels were detected in 3 cases, consisting of 2 cases of primary hyperparathyroidism and one of multiple myeloma. <br>Conclusions: On screening for primary hyperparathyroidism in Ningen Dock examinees, we detected 2 cases of primary hyperparathyroidism. The first case was the 817th examinee and the second case the 1,737th examinee. The detection rate for hyperparathyroidism in Ningen Dock seems to be about 1/1,000.

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