Relationship between Uric Acid Levels and Obesity-related Factors, Especially Visceral Fat

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  • Fukui Toshiki
    Center for Preventive Medical Treatment, NTT West Takamatsu Hospital
  • Maruyama Mie
    Center for Preventive Medical Treatment, NTT West Takamatsu Hospital
  • Yamauchi Kazuhiro
    Center for Preventive Medical Treatment, NTT West Takamatsu Hospital
  • Yoshitaka Sumie
    Center for Preventive Medical Treatment, NTT West Takamatsu Hospital
  • Miyamoto Yu
    Center for Preventive Medical Treatment, NTT West Takamatsu Hospital
  • Fukami Takaharu
    Center for Preventive Medical Treatment, NTT West Takamatsu Hospital

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  • 肥満関連因子と尿酸値との関係　～特に内臓脂肪との関連について～
  • ヒマン カンレン インシ ト ニョウサンチ ト ノ カンケイ : トクニ ナイゾウ シボウ ト ノ カンレン ニ ツイテ

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Abstract

Objective: Five years have passed since the Specific Health Examination and Specific Health Guidance were introduced with the aim of reducing metabolic syndrome. In their 6th year, these programs have entered a second phase, with some revisions. However, while hyperuricemia is recognized to be a lifestyle-related disease that is closely associated with obesity and metabolic syndrome, uric acid levels are not included in the basic tests. In the present study, we therefore examined a relationship between obesity-associated factors and uric acid levels.<br>Methods: The subjects were 909 persons (708 males and 201 females, average age 48.7 years, 45.3 years, respectively) who received a health check-up at our facility, in which visceral fat area was measured by CT scan. We examined a relationship between uric acid levels and the obesity-related factors, which are BMI, waist circumference, visceral fat area, subcutaneous fat area, and visceral fat/subcutaneous fat area ratio. We also examined a relationship between levels of uric acid and serum creatinine, an indicator of kidney function.<br>Results: The mean uric acid level was 6.1 ± 0.1 mg/dL in males and 4.3 ± 0.1 mg/dL in females. There was a significant positive correlation between all obesity-related factors showed and uric acid, with visceral fat area having the highest correlation coefficient (r=0.322, p<0.0001). The correlation coefficient between the uric acid level and all obesity-related factors was greater in females. The significant positive correlation between uric acid and serum creatinine showed that serum uric acid and renal function were closely related.<br>Conclusions: The findings of our study revealed that, among obesity-related factors, visceral fat was the most closely associated with serum uric acid levels and suggest that it should be included in the Specific Health Examination, aiming at further reducing metabolic syndrome. The closer relationship in females between uric acid levels and obesity-related factors including visceral fat is of interest and should be the subject of further studies.

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