Examination of Cut-off Values for Visceral Fat Area and Waist Circumference in Metabolic Syndrome

Imoto Takayuki, Kato Chiharu, Yokochi Takashi, Yoshikane Naofumi, Misu Naoko, Bessho Yuji, Sakai Yasuko, Iwata Masamitsu

doi:10.11320/ningendock.25.541

Objective: The purpose of this study was to examine cut-off points for visceral fat area (VFA) and waist circumference (WC) in Japanese men and women, by studying a relationship between VFA and plasma adiponectin density. <br>Subjects and Methods: Our study population consisted of 8,470 men (47.3 ± 8.2 years) and 1,626 women (47.5 ± 4.7 years), who underwent a medical examination at TOYOTA Health Support Center WELPO. Using receiver operating characteristic [ROC] curve analysis, we determined the optimal cut-off points for VFA and WC - those fulfilling the presence of 2 or 3 factors from among hypertension, dyslipidemia, and hyperglycemia, which are related to metabolic syndrome (MetS). In addition, the gender-specific WC cut-off point equivalent to the VFA cut-off point, was determined using simple regression analysis between VFA and WC. Subjects were divided into groups according to VFA in 20 cm² intervals, and the mean density of plasma adiponectin was compared among them. <br>Results: ROC curve analysis showed that the optimal cut-off points for VFA and WC were 76.3 cm² & 84.2 cm in men and 47.3 cm² & 80.5cm in women, respectively. By regression analysis, WC values corresponding to the VFA cut-off point were 85.2cm in men and 80.1cm in women. In WC groups over 60-80 cm² in men and over 40-60 cm² over in women, there was no significant difference in the relationship between VFA and the mean density of plasma adiponectin. This result suggests that there would be a lower limit of adiponectin secretion for higher values of VFA. <br>Conclusion: It would be advisable to review the Japanese waist circumference criteria for MetS, especially in women.

Examination of Cut-off Values for Visceral Fat Area and Waist Circumference in Metabolic Syndrome

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