<I>In vitro</I> pharmacological activities of the extracts from red ant <I>Formica aquilonia</I> as potential therapeutic agents

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  • PIAO Chunhong
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University College of Food Engineering, Jinlin Agricultural University
  • TACHIKAWA Eiichi
    Department of Pharmacology, Faculty of Pharmacy, Iwate Medical University
  • HU Yaohui
    College of Food Engineering, Jinlin Agricultural University
  • SATO Yoshinori
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
  • YANG Ping
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
  • YAMAMOTO Kei-ichiro
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
  • SHINADA Tetsuro
    Graduate School of Science, Osaka City University
  • SUZUKI Koichi
    Department of Agro-Bioscience, Faculty of Agriculture, Iwate University

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  • In vitro pharmacological activities of the extracts from red ant Formica aquilonia as potential therapeutic agents

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Abstract

The extracts of Chinese red ant Formica aquilonia were screened for cytotoxicity, antioxidation and anti-inflammatory properties, prolyl oligopeptidase (POP) inhibition, and the effect on the catecholamine secretion. Dried ants were successively extracted with hexane, ethyl acetate, aqueous acetone and distilled water. Both the hexane and ethyl acetate extracts exhibited a high level of POP inhibitory activity; ethyl acetate extract was also significantly cytotoxic against the rat liver cancer cells. In the assay with anti-inflammatory assay, the residue of hexane extract suppressed weakly COX-2 activity. Inhibition of the acetylcholine-dependent catecholamine secretion from the bovine adrenal chromaffin cells was most pronounced with the ethyl acetate extract. The aqueous acetone extract exhibited antioxidant activity in a diphenylpierylhydrazyl assay. These results indicate that F. aquilonia contains promising therapeutic agents.

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