Relationship between Urinary Myoinositol Increment before and 2h after a Regulated Meal and Glucose Intolerance (Part 2).

DOI Web Site 28 References

Bibliographic Information

Other Title
  • 食事負荷試験における尿中ミオイノシトールと耐糖能の関係（その2）
  • ショクジ フカ シケン ニ オケル ニョウ チュウ ミオイノシトール ト タイトウノウ ノ カンケイ ソノ 2

Search this article

Abstract

Objective: To assess the potential of urinary myoinositol measurement after a meal to be used in place of that after glucose loading (2).<br>Methods: Fifty-two volunteers who underwent 75-g oral glucose tolerance testing (75gOGTT) were classified according to 1998 WHO criteria. Normal glucose tolerance subjects with a 1 h plasma glucose ≥180 mg/dL were defined as pre-borderline type. On a different day, they underwent a regulated meal load test (MT). Urinary myoinositol was measured before and 2 hours after both OGTT and MT and incremental urinary myoinositol (ΔUMI: myoinositol/creatinine ratio 2 hours after loading - myoinositol/creatinine ratio before loading) was compared between the tests.<br>Results: A good correlation was observed between ΔUMI in OGTT and that in MT (r = 0.796). Lower glucose tolerance was associated with a greater ΔUMI. Setting 10 mg/gCr as a tentative cut-off value in MT for detecting glucose intolerance, ΔUMI was positive in 100% of subjects (8/8) with diabetes mellitus (DM) and 86% (6/7) of those with impaired glucose tolerance (IGT). In OGTT, ΔUMI was positive in 100% of subjects (8/8) with DM and 86% of subjects (6/7) with IGT. Therefore, the positive rates for ΔUMI in OGTT and MT were equivalent.<br>Conclusion: These results indicate that as a non-invasive and sensitive marker of glucose intolerance, ΔUMI in MT is comparable to that in OGTT.

Journal

References(28)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top