Study on Usefulness of AminoIndex<sup>TM</sup> Cancer Screening as a Novel Cancer Screening Method: The Second Report

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  • Yamakado Minoru
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
  • Yamamoto Hiroshi
    Institute for Inovation, Ajinomoto Co., Inc.
  • Shinhara Atsuko
    Institute for Inovation, Ajinomoto Co., Inc.
  • Yamamoto Mai
    Institute for Inovation, Ajinomoto Co., Inc.
  • Tani Mizuki
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
  • Toda Akiko
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital
  • Ishizaka Yuko
    Center for Multiphasic Health Testing and Services, Mitsui Memorial Hospital

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Other Title
  • 新規がん検診としてのアミノインデックス<sub>®</sub>がんリスクスクリーニングの有用性に関する検討　第二報
  • 新規がん検診としてのアミノインデックスがんリスクスクリーニングの有用性に関する検討(第2報)
  • シンキ ガン ケンシン ト シテ ノ アミノインデックス ガン リスクスクリーニング ノ ユウヨウセイ ニ カンスル ケントウ(ダイ2ホウ)

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Abstract

Background: AminoIndexTM Cancer Screening (AICS) was developed as a novel cancer screening test for evaluating the probability of 6 types of cancers (lung, gastric, colorectal, prostate, breast and uterine/ovarian) and is now being applied in practice for this purpose. AICS is based on “AminoIndex Technology” which compares plasma free amino acid (PFAA) concentrations between cancer patients and healthy controls by multivariate analysis. In this study, we report the results of AICS for Ningen Dock examinees as well as those for detailed examinations for those determined to be rank C in AICS. <br>Methods: AICS was conducted for 799 Ningen Dock subjects (494 men, 305 women, average age: 59±11) at Mitsui Memorial Hospital. Rank C subjects were given detailed examinations for each cancer:</B> chest CT for lung, gastro-intestinal fiberscope for gastric, lower intestinal fiberscope for colorectal, PSA and abdominal ultrasonography for prostate, mammography and mammary ultrasonography for breast and cytology and transvaginal sonography for uterine/ovarian cancers, respectively. <br>Results: One case each of gastric, prostate and breast cancer were diagnosed by detailed examinations on rank C subjects. The detection rate of cancer by AICS was 0.38%, which was superior to that of 0.26%, reported for the national survey conducted by Japan Society of Ningen Dock in 2011. Also, many precancerous lesions were detected; such as nodular lung lesions, atrophic gastritis with interstitial metaplasia, high-grade colorectal adenoma and high PSA levels.<br>Conclusion: These results suggested that AICS could be a novel cancer screening test. More study is recommended to further clarify its usefulness.

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