Investigation of CKD without Proteinuria
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- Miyamoto Yuichi
- Health Management Center of Shinkoga Clinic
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- Sadasima Eiji
- Department of Biostatistics,Graduate School of Medicine, Kurume University Clinical laboratory and Department of Radiology, Shinkoga Hospital
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- Koyanagi Noriaki
- Health Management Center of Shinkoga Clinic
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- Yoshida Tuyosi
- PET Center of Koga Hospital 21
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- Otubo Yosihiko
- Health Management Center of Shinkoga Clinic
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- Ono Ken
- Clinical laboratory and Department of Radiology, Shinkoga Hospital
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- Kaneko Kouichirou
- PET Center of Koga Hospital 21
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- Izumi Kanako
- Health Management Center of Shinkoga Clinic
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- Matui Tomoko
- Health Management Center of Shinkoga Clinic
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- Yamaura Risa
- Health Management Center of Shinkoga Clinic
Bibliographic Information
- Other Title
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- 蛋白尿陰性CKDの検討
- タンパク ニョウ インセイ CKD ノ ケントウ
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Abstract
Objective: Most chronic kidney disease (CKD) patients do not have proteinuria. We investigated risk factors of CKD without proteinuria and CKD progression in cases we had encountered.<br>Methods: Among 8,357 persons of 20 years and older who were examined at our health check-up center from 2002 onwards, we extracted those who had an eGFR (estimated glomerular filtration rate) of less than 60 mL/min/1.73m2 and conducted multivariate logistic regression analysis regarding the risk factors of sex, age, urine tests, uric acid, BMI, hypertension, hyperlipidemia, diabetes and smoking. We examined the course of eGFR in CKD subjects without proteinuria for whom 3-5 years of follow-up was possible. <br>Results: Examinees of over 60 years at stage 3 CKD accounted for 15.76% of the total. Those with an eGFR of 50 or over but less than 60 accounted for 86% and those negative for proteinuria 86%. The risk factors for stage 3 CKD stage subjects overall in decreasing order of precedence were age, hyperuricemia, proteinuria, hypertension, and sex while those for CKD subjects without proteinuria in decreasing order were age, hyperuricemia, and hypertension. In 3-5 years (average 4.32 years) of follow-up, no significant decrease in eGFR was observed in subjects without proteinuria.<br>Conclusion: 86% of stage stage 3 CKD cases discovered in health check-ups, have an eGFR of 50 mL/min/1.73m2 or above, the criterion for referral of patients for specialist examinations, and absence of proteinuria. Hyperuricemia is an important risk factor (odds ratio: 3.191) for CKD without proteinuria and interventions are considered necessary when it is present. We felt that proteinuria should be included as a stratified risk factor for CKD.
Journal
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- Official Journal of Japan Society of Ningen Dock
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Official Journal of Japan Society of Ningen Dock 25 (5), 811-817, 2011
Japan Society of Ningen Dock
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Details 詳細情報について
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- CRID
- 1390001205235095296
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- NII Article ID
- 10031145756
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- NII Book ID
- AA12055286
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- ISSN
- 21865027
- 18801021
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- NDL BIB ID
- 11062804
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- CiNii Articles
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- Abstract License Flag
- Disallowed