Evaluation of Dyslipidemia Using LDL-C (Direct Method and Friedewald Formula) in Health Check-ups

DOI Web Site

Bibliographic Information

Other Title
  • 一般健診におけるLDL-C（直接法，F式法）を用いた脂質代謝異常判定の問題点
  • イッパンケンシン ニ オケル LDL-C(チョクセツホウ,F シキホウ)オ モチイタ シシツ タイシャ イジョウ ハンテイ ノ モンダイテン

Search this article

Description

Objective: We compared LDL-C measurement by direct assay with LDL-C calculated by Friedewald's formula (FF) in health check-ups. <br>Methods: Our subjects were 3,545 people (males: 3,545, females: 1,399,mean age:50.9±6.7)who came to our health check-up center. We evaluated the TG coefficient using statistical analysis. <br>Results: The Student's paired t-test showed that values measured by D-LDL-C (Direct assay) were significantly higher than those calculated by F-LDL-C (Friedewald's formula). Regression analysis revealed a strong correlation between calculated and measured LDL-C. D-LDL-C was strongly correlated with TC and non-HDL-C. The percentage difference between calculated and measured values [(F-LDL-C - D-LDL-C)/(D-LDL-C) x 100] was significantly correlated with TG, showing a downward deviation with increasing TG levels. The TG coefficient calculated by FF was 0.16±0.06 (SD) and 0.1 calculated by a multiple regression equation from TC, HDL-C and TG values. It was 0.12 from a scatter plot of TG vs. VLDL-C. Statistical analysis showed that when TG was low, the TG coefficient varied widely, whereas when TG was between 100 and 350mg/dL, no significant difference between calculated and measured LDL-C values was observed. <br>Conclusion: D-LDL-C was highly correlated with F-LDL-C, and D-LDL-C tended to be higher than F-LDL-C with increasing TG levels. The TG coefficient varied widely according to TG levels. Therefore, the calculation of TC using FF should be restored for lipid metabolism management in health check-ups.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top