Development of Coronary Heart Disease and Cerebral Stroke in Japanese Elderly Patients with Nonalcoholic Fatty Liver Diseases

DOI Web Site 参考文献31件
  • Kyoko Ogawa
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Yuki Ohmoto-Sekine
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Shigeko Hara
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Chikao Okuda
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Kazuhisa Amakawa
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Satao Arimoto
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Hisahito Kato
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Shiun Dong Hsieh
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Maho Tanabe
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Chie Ogata
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Makiko Ishihara
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Hiroshi Tsuji
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital
  • Kazumi Saito
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine
  • Satoru Kodama
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine
  • Hirohito Sone
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital Department of Internal Medicine, University of Tsukuba Institute of Clinical Medicine
  • Yasuji Arase
    Department of Health Management Center and Okinaka Memorial Institute for Medical Research, Toranomon Hospital

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Objective: Metabolic syndrome enhances coronary heart disease and cerebral stroke. However, few longitudinal studies have been conducted on the incidence of coronary heart disease and cerebral stroke in Japanese patients with non-alcoholic fatty liver disease (NAFLD) and the risk factors for its development. <br>Methods: A total of 1,798 NAFLD patients with an age of ≥60 years were enrolled. The primary event was the first onset of coronary heart disease or cerebral stroke. Independent factors associated with the incidence rate of such events were analyzed by the Kaplan-Meyer method and the Cox proportional hazard model. The mean observation period was 7.5 years.<br>Results: The number of cases of coronary heart disease or cerebral stroke that developed was 137. The 10th year cumulative development rate was 11.7% in the NAFLD patients. Cox proportional hazards analysis revealed the following: 1) Coronary heart disease occurred with statistical significance when patients had poor control of blood pressure, smoking, low high density lipoprotein level, and high glucose level. 2) Ischemic stroke occurred with statistical significance when patients had poor control of blood pressure, an age of ≥70 years, and high glucose level. 3) Hemorrhagic stroke occurred with statistical significance when patients had poor control of blood pressure, age ≥70 years, low albumin level of <3.9 g/dL and high aspartate aminotransferase to platelet ratio index. <br>Conclusion: Our study indicates that the risk factors for the development of vascular disease are different for coronary heart disease, ischemic stroke and hemorrhagic stroke in Japanese elderly patients with NAFLD.

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