Microbiological Studies of Coli-aerogenes Bacteria

DOI DOI DOI DOI DOI ほか10件をすべて表示 一部だけ表示 被引用文献2件 参考文献10件 オープンアクセス
  • KATAGIRI Hideo
    Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
  • TOCHIKURA Tatsurokuro
    Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University
  • SUZUKI Yukio
    Department of Agricultural Chemistry, Faculty of Agriculture, Kyoto University

書誌事項

タイトル別名
  • Microbiological Studies of <i>Coli</i>-<i>aerogenes</i> Bacteria
  • Microbiological studies of Coli-aerogenes bacteria. II. Oxidative fermentation of glucose
  • Part VI. The Action of Antibiotics on Bacterial Respiration and α-Ketoglutaric Acid-Fermentation

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説明

Dihydrostreptomycin not only depressed the bacterial accumulation of α-ketoglutarate from a variety of carbonaceous substances including glucose, acetate, pyruvate, lactate and C4-dicarboxylic acids such as succinate, fumarate and malate, but also stimulated the bacterial oxidation of α-keto-glutarate under suitable conditions. The dihydrostreptomycin-resistive strains were found to induce α-ketoglutaric acid-fermentation, and an explanation was put forward for the mechanism of development of drug-resistance. Chloramphenicol was observed to inhibit the α-ketoglutarate-synthe-sizing system in the bacteria without causing any inhibition of the oxidative removal of a variety of carbonaceous substances. It was concluded that the bacteria possessed both oxidation oz respiration system; one was sensitive to the drug and the other non-sensitive. The mode of action of streptomycin or chloramphenicol upon the formation of an adaptive enzyme (protein synthesis) was discussed here, based on the results of present investigations. Tetracycline and the related compounds were ascertained to greatly inhibit the consumption of substrates by the bacteria.

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