Cell sheet engineering for regenerative medicine: From the viewpoint of inflammation
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- Yamato Masayuki
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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- Sekine Hidekazu
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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- Yang Joseph
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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- Sekiya Sachiko
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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- Haraguchi Yuji
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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- Shimizu Tatsuya
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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- Okano Teruo
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University
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Description
Here, we'd like to summarize the brief history of regenerative medicine, finally focusing on cell sheet engineering developed by us. Conventionally, two methods for cell delivery to host tissues have been utilized: one is single cell suspension injection, and the other is the utilization of biodegradable scaffolds, although both have the intrinsic shortcomings. In order to overcome the shortcomings, we initiated the development of a new type of tissue engineering ten years ago. Using temperature-responsive culture surfaces, cultured cells can be harvested as intact sheets by simple temperature changes, thereby avoiding the use of proteolytic enzymes. Cell sheet engineering therefore allows for tissue regeneration by either direct transplantation of cell sheets to host tissues or the creation of thick constructs via the layering of individual cell sheets. In this review, we compare these three with referring to adverse inflammatory effects.
Journal
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- Inflammation and Regeneration
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Inflammation and Regeneration 27 (3), 156-164, 2007
The Japanese Society of Inflammation and Regeneration
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Details 詳細情報について
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- CRID
- 1390001205256637440
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- NII Article ID
- 130004482180
- 10022601545
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- NII Book ID
- AA11508953
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- ISSN
- 18808190
- 18809693
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- NDL BIB ID
- 8845479
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed