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- Yamashita Takayuki
- Laboratory of Molecular Genetics, The Institute for Molecular and Cellular Regulation, Gunma University
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- Oda Tsukasa
- Laboratory of Molecular Genetics, The Institute for Molecular and Cellular Regulation, Gunma University
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- Sekimoto Takayuki
- Laboratory of Molecular Genetics, The Institute for Molecular and Cellular Regulation, Gunma University
この論文をさがす
抄録
Translesion DNA synthesis (TLS) is an essential mechanism for DNA damage tolerance during genome duplication by bypassing DNA lesions with use of specialized low-fidelity polymerases. Thus, TLS is inherently mutagenic, which is presumed to be involved in cancer initiation and progression. Increasing attention has focused on post-translational regulatory mechanisms of TLS polymerases, including covalent modification (e.g., phosphorylation) and proteasomal degradation. In this review article, we focus on our findings on Hsp90-mediated regulation of TLS polymerases and discuss potential pharmacological effects of Hsp90 inhibitors in cancer therapy.<br>
収録刊行物
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- Genes and Environment
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Genes and Environment 34 (2), 89-93, 2012
日本環境変異原学会
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詳細情報 詳細情報について
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- CRID
- 1390001205256658048
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- NII論文ID
- 10030311653
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- NII書誌ID
- AA1212552X
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- COI
- 1:CAS:528:DC%2BC38XhtVGgsrbO
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- ISSN
- 18807062
- 18807046
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- NDL書誌ID
- 023634514
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可