Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against <i>N</i>-Alkyl-<i>N</i>-nitrosoureas-induced Mutagenicity Using the <i>umu</i> Test
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- Inami Keiko
- Faculty of Pharmaceutical Sciences, Tokyo University of Science Kyoritsu University of Pharmacy
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- Takada Masashi
- Kyoritsu University of Pharmacy
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- Itoh Kei
- Kyoritsu University of Pharmacy
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- Ishikawa Satoko
- Kyoritsu University of Pharmacy Faculty of Pharmacy, Keio University
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- Mochizuki Masataka
- Faculty of Pharmaceutical Sciences, Tokyo University of Science Kyoritsu University of Pharmacy
Bibliographic Information
- Other Title
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- Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test
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Abstract
Carcinogenic N-methyl-N-nitrosourea (MNU) has been reported to be formed in vivo and suspected to be a causative agent for human cancer. Therefore, for cancer chemoprevention it is important to find compounds which inhibit N-alkyl-N-nitrosoureas-induced mutagenicity. The inhibitory effect of plant extracts against MNU mutagenicity was evaluated using the umu test. Among thirty aqueous extracts, derived from medicinal plants, seventeen extracts inhibited N-alkyl-N-nitrosoureas-induced mutagenicity using Salmonella typhimurium TA1535/pSK1002. Nine aqueous extracts; Astragalus Root, Bupleurum Root, Cimicifuga Rhizome, Cnidium Rhizome, Glycyrrhiza, Paony Root, Polygonatum Rhizome, Poria Sclerotium, and Processed Ginger, moderately inhibited N-alkyl-N-nitrosoureas-induced mutagenicity (IC50>7.0 mg/mL), and eight aqueous extracts; Cinnamon Bark, Cinnamon Twig, Dodder Seed, Malaytea Scurfpea Fruit, Phellodendron Bark, Prunella Spike, Scisandra Fruit, and Suberect spatholobus Stem strongly inhibited N-alkyl-N-nitrosoureas-induced mutagenicity (IC50<7.0 mg/mL) in Salmonella typhimurium TA1535/pSK1002. An aqueous extract from Suberect spatholobus Stem showed the most potent antimutagenic effects against N-alkyl-N-nitrosoureas.<br>
Journal
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- Genes and Environment
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Genes and Environment 36 (2), 33-38, 2014
The Japanese Environmental Mutagen Society
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Details 詳細情報について
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- CRID
- 1390001205256894592
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- NII Article ID
- 130004943658
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- NII Book ID
- AA1212552X
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- ISSN
- 18807062
- 18807046
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- NDL BIB ID
- 025478580
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed