Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against <i>N</i>-Alkyl-<i>N</i>-nitrosoureas-induced Mutagenicity Using the <i>umu</i> Test

  • Inami Keiko
    Faculty of Pharmaceutical Sciences, Tokyo University of Science Kyoritsu University of Pharmacy
  • Takada Masashi
    Kyoritsu University of Pharmacy
  • Itoh Kei
    Kyoritsu University of Pharmacy
  • Ishikawa Satoko
    Kyoritsu University of Pharmacy Faculty of Pharmacy, Keio University
  • Mochizuki Masataka
    Faculty of Pharmaceutical Sciences, Tokyo University of Science Kyoritsu University of Pharmacy

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  • Assessment of the Antimutagenic Effects of Aqueous Extracts from Herbal Medicines against N-Alkyl-N-nitrosoureas-induced Mutagenicity Using the umu Test

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Abstract

Carcinogenic N-methyl-N-nitrosourea (MNU) has been reported to be formed in vivo and suspected to be a causative agent for human cancer. Therefore, for cancer chemoprevention it is important to find compounds which inhibit N-alkyl-N-nitrosoureas-induced mutagenicity. The inhibitory effect of plant extracts against MNU mutagenicity was evaluated using the umu test. Among thirty aqueous extracts, derived from medicinal plants, seventeen extracts inhibited N-alkyl-N-nitrosoureas-induced mutagenicity using Salmonella typhimurium TA1535/pSK1002. Nine aqueous extracts; Astragalus Root, Bupleurum Root, Cimicifuga Rhizome, Cnidium Rhizome, Glycyrrhiza, Paony Root, Polygonatum Rhizome, Poria Sclerotium, and Processed Ginger, moderately inhibited N-alkyl-N-nitrosoureas-induced mutagenicity (IC50>7.0 mg/mL), and eight aqueous extracts; Cinnamon Bark, Cinnamon Twig, Dodder Seed, Malaytea Scurfpea Fruit, Phellodendron Bark, Prunella Spike, Scisandra Fruit, and Suberect spatholobus Stem strongly inhibited N-alkyl-N-nitrosoureas-induced mutagenicity (IC50<7.0 mg/mL) in Salmonella typhimurium TA1535/pSK1002. An aqueous extract from Suberect spatholobus Stem showed the most potent antimutagenic effects against N-alkyl-N-nitrosoureas.<br>

Journal

  • Genes and Environment

    Genes and Environment 36 (2), 33-38, 2014

    The Japanese Environmental Mutagen Society

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