A case of paclitaxel-induced peripheral neuropathy successfully treated with lafutidine and tocoferol nicotinate

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  • Mita Ayako
    Department of Palliative Medicine, Japan Community Health Care Organization Kobe Central Hospital
  • Yamana Junko
    Department of Palliative Medicine, Japan Community Health Care Organization Kobe Central Hospital
  • Kodo Morihiko
    Department of Palliative Medicine, Japan Community Health Care Organization Kobe Central Hospital

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  • パクリタキセルによる末梢神経障害に対しラフチジンとトコフェロールニコチン酸エステルの併用が著効した1例

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We report a case of Paclitaxel-induced peripheral neuropathy successfully treated with lafutidine and tocoferol nicotinate(TN). Case Report: A 72-year-old male patient with pulmonary adenocarcinoma of left upper lobe, and metastasis of the liver. He suffered from the feelings of pins and needles of the limbs after the paclitaxel treatment, and admitted to our hospital. There was almost no remarkable change in the feelings of pins and needles with TN at 300mg per day, however, after addition of lafutidine at 20mg per day, those symptoms improved markedly, and he came to be able to walk alone. Therefore we reduced the dose of TN, those symptoms got worse. We restored TN to 300mg per day again, then these symptoms got better and he came to walk alone out of doors again. Consideration: Administration of lafutidine with TN improved the paclitaxel-induced peripheral neuropathy. Since the speed of the regeneration of the peripheral neurons is slow and changing the dose of TN affected the symptoms immediately, we considered that the improvement of the feelings of pins and needles of the limbs is due to the synergistic effect of the increase of the microvascular bloodflow of TN and lafutidine, and the effect of desensitization through the capsaicin-sensitive afferent neurons, although the hypothesis needs further investigation.

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