Globally Harmonized System on Hazard Classification and Labeling of Chemicals and Other Existing Classification Systems for Germ Cell Mutagens

DOI Web Site 参考文献23件
  • Morita Takeshi
    Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences
  • Hayashi Makoto
    Division of Genetics and Mutagenesis, National Institute of Health Sciences
  • Morikawa Kaoru
    Division of Safety Information on Drug, Food and Chemicals, National Institute of Health Sciences

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The Globally Harmonized System (GHS) on hazard classification and labeling of chemicals will be implemented globally by 2008. The GHS includes (a) harmonized criteria for classifying chemicals and chemical mixtures according to their health, environmental and physical hazards, and (b) harmonized hazard communication elements, including requirements for labeling and safety data sheets. Germ cell mutagenicity is included in the GHS health hazard classes in addition to carcinogenicity. This means increased significance for then results of genetic toxicology testing for the classification of chemicals. GHS requires the classification of chemicals if they are germ cell mutagens (categories 1A, 1B and 2) or not. Several classification systems for germ cell mutagens have been proposed in the EU, Germany, US, Canada, in advance of the adoption of the GHS. In this paper, these classification systems including GHS are introduced and summarized to provide the basis of the hazard classification of germ cell mutagens. Though the objectives, target audiences and criteria of these classification systems are different, the GHS will become standard for hazard classification. Hazard classification is a significant first step in risk communication. Further development of risk evaluation criteria and communication on germ cell mutagens is expected.<br>

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