Identification and evaluation of high-titer anti-Sox Group B antibody in limbic encephalitis

DOI Web Site 被引用文献1件 参考文献24件
  • Tada Hirobumi
    Department of Physiology, Keio University School of Medicine JSPS (Japan Society for the Promotion of Science) research fellow
  • Ishii Seiji
    Department of Physiology, Keio University School of Medicine
  • Kimura Hiroaki
    Department of Neurology, Keio University School of Medicine
  • Hattori Hidenori
    Department of Neurology, Keio University School of Medicine Department of Pathology, Joint Program in Transfusion Medicine, Harvard Medical School, and Department of Laboratory Medicine, Children's Hospital Boston
  • Okada Yohei
    Department of Physiology, Keio University School of Medicine JSPS (Japan Society for the Promotion of Science) research fellow Department of Neurology, Nagoya University Graduate School of Medicine
  • Suzuki Norihiro
    Department of Neurology, Keio University School of Medicine
  • James Okano Hirotaka
    Department of Physiology, Keio University School of Medicine

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We evaluated a high titer autoantibody detected in a limbic encephalitis patient with possible lung carcinoma. The patient's autoantibody reacted with BrdU-incorporated dividing cells in the subventricular zone of lateral ventricle and dentate gyrus of the hippocampus, the neurogenic regions of the adult brain, and most of the immunoreactive cells are thought be proneural cells. Characterization of the autoantigen by Western blotting and immunoabsorption has shown that the antibody in the patient's serum binds to Sox Group B proteins but not to authentic paraneoplastic antigens. Our results indicate that the neural stem/progenitor cell population would be a target of the autoantibody in the adult brain.

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