Error-prone Gene mucAB Variants in Escherichia coli Plasmids from Japanese Donors

DOI Web Site 27 References Open Access
  • Tanooka Hiroshi
    Biological Effects Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
  • Tatsumi Kouichi
    Biological Effects Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
  • Tsuji Hideo
    Biological Effects Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
  • Ochiya Takahiro
    Section for Studies on Metastasis, National Cancer Center Research Institute
  • Hirokawa Hideo
    Life Science Institute, Sophia University
  • Mitsuoka Tomotari
    Department of Biomedical Science, Faculty of Agriculture, The University of Tokyo

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Description

Variants of the error-prone gene, mucAB, were found in Escherichia coli plasmids from 3 out of 63 healthy Japanese donors. As compared with mucAB of pKM101, one contained unaltered mucA only, while two others contained full-sized, mutated mucAB with mutation-enhancing activity in E. coli. Possible interaction between bacterial plasmid genes and host humans was discussed.<br>

Journal

  • Genes and Environment

    Genes and Environment 31 (4), 119-122, 2009

    The Japanese Environmental Mutagen Society

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