Bio-engineered scaffold with fibroblasts for tracheal regeneration in a rabbit model

DOI Web Site 1 Citations 33 References
  • Okano Wataru
    Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
  • Nomoto Yukio
    Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
  • Kobayashi Ken
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
  • Miyake Masao
    Department of Cell Science, Institute of Biomedical Sciences, School of Medicine, Fukushima Medical University, Fukushima, Japan
  • Suzuki Teruhisa
    Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
  • Tada Yasuhiro
    Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
  • Nakamura Tatsuo
    Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
  • Watanabe Mutsumi
    Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan
  • Omori Koichi
    Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan

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Some patients with malignant or stenotic inflammatory lesions of the trachea require tracheal resection and reconstruction. Conventionally, it is difficult to reconstruct tracheal defects by either end-to-end anastomosis or autologous tissue implantation.<BR>Recently, a few studies on tracheal regeneration using scaffolds have been reported. Collagen-conjugated prothesis have been used for tracheal reconstruction in the clinical application. The problem of this tracheal prosthesis is delay of epithelial regeneration to avoid possible infection.<BR>A bio-engineered scaffold consisted of collagen sponge and polypropylene mesh with fibroblasts was developed for accelerating tracheal regeneration.<BR>The regenerated tracheas were examined by bronchoscopic findings, histological finding and measurement of average thickness of the regenerated trachea. A bio-engineered scaffold was observed to induce more rapid re-epithelization in the large tracheal defect of a rabbit model. This method appears to be feasible for clinical use after further experiments investigating its efficacy and safety.

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